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ADVANCES IN LIPID RESEARCH Vol.12

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The current volume of Advances in Lipid Research brings together topics which range across the field of lipid metabolism. As in the past, the chapters in this book represent the most advanced knowledge in the specific areas represented.

The opening review is devoted to a discussion of the relationships between plasma and tissue lipids and atherosclerosis. Understanding the dynamics of exchange of plasma lipoproteins with aortic tissue is the basis of understanding the etiology of this disease and, hopefully, the approaches to therapy. A relatively recent research tool, but one which has already shown great utility, is the study of metabolism using cultured cells.

The second paper of this book is devoted to a discussion of lipid metabolism in cultured cells. Cell systems hold promise of understanding mechanisms of lipidoses and may aid in their diagnosis. All phases of lipid metabolism are discussed in this review. Research on dietary effects on lipid metabolism has progressed beyond descriptions of the lipid content of blood and tissues. The "what" of various regimens is known and we are now asking "how?" The third article describes the influences of various dietary components on the specific enzymes of fatty acid and cholesterol biogenesis. This discussion includes enzyme induction, syn- thesis, and degradation. Membrane function, especially the metabolic behavior of one important membrane component, is discussed in the fourth paper. This article is devoted to an exposition of the role of phospholipids in transport and enzymic reactions. This discussion in- cludes membrane fluidity and aspects of lipid-protein interactions. Thyroid hormone exerts specific effects on cholesterol and bile acid metabolism. It has been implicated, via these effects on lipids, in the etiology of atherosclerosis. The lipids of the thyroid gland, however, have never been fully investigated. The fifth review is devoted to a discussion of thyroid lipids and their physiologic role. Thyroid lipids are primarily triglycerides; their synthesis and hydrolysis may aid in the regulation of glucose metabolism by this gland. The designation "glycolipid" covers a variety of structures. A newcomer to this area is the class of glycolipids known as glycosyl glycerides. These compounds are found in plants, bacteria, and in animal tissues. The chemistry and biological function of glycosyl glycerides is discussed in the sixth article. The last paper is devoted to the physiopathology of the biguanidines, a class of oral hypo- glycemic agents whose relationship to carbohydrate and lipid metabolism s only now being established

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547.915.95:577.1(058) PAO a

Perpustakaan PPKS Medan Lt. 1 (547.915.95:577.1(058))

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Series Title

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Call Number

547.915.95:577.1(058) PAO a

Publisher

New York : Academic Press., 1974

Collation

xix, 415 hal.: ill.;23,5 cm

Language

English

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Classification

547.915.95:577.1(058)

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Carrier Type

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Edition

12

Subject(s)

Research

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