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ADVANCES IN LIPID RESEARCH Vol. 10
This volume of Advances in Lipid Research is devoted to several spe- cial areas of lipid research which are becoming important; new frontiers of established areas of interest are also treated.
The first chapter discusses the application of electron microscopic techniques to the analysis of plasma lipoproteins, an entirely novel way of studying lipoprotein structure. The second article provides a new look at a topie that has piqued scientific interest for a long time-possible modification of reticuloendothelial function by lipids. Present awareness of the role played by lipids in membrane structure and function intro- duces new aspects to this field. The role of lipids in cellular, humoral, and immune responses is discussed in the second chapter. The third contribu- tion summarizes current knowledge of the microsomal enzymes of sterol biosynthesis. With the extension of studies of lipid synthesis to tissue culture and with new methods of separation and identification of sterols, this paper should be useful to workers in a number of areas. The fifth chapter provides the latest information on one aspect (enzymatic syn- thesis and degradation) of glycerol lipids which contain ether bonds. This type of lipid has been found in an increasing number of tissues and cells, and its metabolic role is only now being delineated. Brain and nervous tissue research continues to expand with work covering normal development as well as genetic defects. Two chapters explore lipid neurochemistry in depth: the fourth chapter covers brain lipids (fatty acids, phospholipids, sphingolipids, galactosyl lipids, and sterols), whereas the sixth chapter is somewhat broader in scope and discusses lipids of the entire nervous system and their variation with age. Both articles contribute greatly to the knowledge of lipid neurochemistry.
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