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ANNUAL REVIEW OF BIOCHEMISTRY Vol VIII
With the writing of this introduction, the eighth volume of the Annual Review of Biochemistry goes to press. We trust that it will receive the same cordial reception with which its predecessors have been greeted.
The usefulness of the Review appears to be determined by the extent to which it surveys the progress of investigation in the whole field of biochemical endeavour and also by the extent to which the reviews are critically prepared. Year by year it is becoming increas- ingly difficult to attain these objectives. Faced by the very evident impossibility of adequately reviewing the greater number of pub- lished works in this rapidly expanding discipline, we have felt driven to the alternative solution-the publication of reviews in which, in the judgment of the authors, the contributions of major significance are critically appraised. We have felt encouraged in so doing through the friendly advice of a number of colleagues, in this country and abroad, who have urged upon us the desirability of asking the authors of re- views to adhere to the critical approach and to attempt to give co- herent pictures of the present status of the respective subjects.
Such, unquestionably, is the intent of almost all who have been good enough to give so unstintingly of their time in the preparation of these reviews. We are confident that few, indeed, have an inherent preference for the mere cataloguing of papers. We realize, however, that a reviewer, eager to include as much of the published work as space permits, sometimes sacrifices much of the critical quality that is so desirable and, without originally intending to do so, prepares a review which is comprehensive but uncritical.
It is our conviction that the Annual Review of Physiology, pub- lished as a companion volume, will considerably ease the trials of the reviewer. We hope that in the planning of future volumes of both Reviews it will be possible to recognize the deep penetration of bio- chemistry into physiology by transferring to the Annual Review of Physiology much subject matter which, hitherto, the reviewers have felt obliged to include in the Annual Review of Biochemistry. The restriction of the latter to investigations of a more chemical character will permit a more precise definition of the field to be covered and will make possible a close integration of the material in both Reviews.
To the reviewers, especially, but also to the many who have aided us with advice, by the sending of reprints of their publications to the authors of the reviews, and by help in many other ways, we extend our warmest thanks. Our sense of gratitude in these matters deepens with the publication of each succeeding volume as we become more and more conscious of the difficulties involved.
We greatly regret that the review on the "Nucleic Acids, Purines, and Pyrimidines," announced in the descriptive circulars, failed to arrive in time for publication.
To Dr. James H. C. Smith we are much indebted for his invaluable help as associate editor.
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