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ANNUAL REVIEW OF BIOCHEMISTRY Vol. III
n introducing the third volume of the Review to its readers it is only fitting that we should gratefully acknowledge the favorable re- ception which its predecessors have enjoyed. We feel encouraged to believe that the Review is beginning to serve effectively the purposes for which it was initiated.
Nevertheless we are acutely aware of a number of formidable diffi- culties, not the least of which is to compass adequately within 500 or 600 pages the literature in the expanding field of biochemistry. In some instances the reviewer has found it possible to include within his survey of a subject only a third or a fourth of the papers which might be deemed worthy of mention if the limitations upon length were less rigorous. But even at the expense of omitting reference to many papers, we are disposed to believe that critical surveys of the literature, though less comprehensive, are of more value to users of the Review than uncritical compendia.
Adoption of this policy imposes upon the reviewer the very diffi- cult task of selecting the papers from which is to be woven his survey of the subject. Overlooking the obvious fact that many papers are necessarily omitted because of their doubtful quality and others are inadvertently neglected, it is but fair to mention that an even greater number are excluded because they pertain to certain phases of the subject which in the judgment of the reviewer might be treated more satisfactorily in a later volume or by another reviewer.
Indeed, certain of the subjects which by tradition and sustained research constitute substantial chapters in biochemistry are themselves so broad that it is not feasible within a brief review to treat satisfac- torily each and every aspect. Some problems of great biochemical in- terest penetrate far into the sister sciences of physiology, anatomy, and physical and organic chemistry. Since more than one of the subjects embraced by the Review enjoy this diversity of interest and approach, the task of the reviewer becomes increasingly difficult. It is hoped that the policy of fluidity in authorship to which we have turned will not only lighten the burden upon each contributor but will permit ex- pression of that diversity of interest and outlook which characterizes investigation in any of the numerous fields of biochemistry.
We have also decided to include from year to year occasional re- views on topics of timely nature in which a lively interest has recently developed and significant advances been made. In consequence the tissue and another on biochemical studies in the field of dentistry aiso Volume IV is expected to contain a review on choline and related compounds, and one on growth substances in plants.
It is convenient to distinguish such topics clearly from those others which by universal consent constitute the traditional divisions of the subject. These will continue to receive review at annual or biennial intervals.
To add to the quality and usefulness of the Review we feel obliged again to request of its readers advice and critical suggestions on mat ters of authorship, content, and general policy. We cannot refrain from expressing here our indebtedness to those who have been good enough to write to us on such matters. We would also mention ap preciatively the courteous aid extended by many laboratories in sup- plying the reviewers with reprints of their recent publications.
It is with a deep sense of obligation that we associate ourselves with the many readers of the Review who have had occasion to feel especially grateful to the reviewers for their labors. Whatever merit the Review possesses is due entirely to their generous co-operation.
To the Stanford University Press we continue to be indebted for its patience and care in composition, for the excellence of its workman- ship, and for its cordial co-operation throughout
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