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ANNUAL REVIEW OF BIOCHEMISTRY Vol. II
The reception enjoyed by the first volume of the Review has been so cordial that a few words of acknowledgment may not be inappro priate as an introduction to the present volume.
First of all, we feel urged to mention the warm co-operation re- ceived from those who have shared in the authorship of the Review and to indicate something of the difficulties under which they have labored. Doubtless the most vexing problem has been that presented by the severe limitations imposed upon the length of reviews. The assignments of space were not as generous as we would have wished and the authors frequently found themselves obliged to eliminate ruthlessly paragraph after paragraph of manuscript. To the reviewer there are only two solutions to such a problem, neither of which is ideal. Either a superficial and hasty mention may be made of most of the papers appearing within the period under review, or a portion may be selected for more exhaustive and critical analysis. Although reviews of the former type are of obvious value for bibliographic purposes, we have come to believe that surveys of a less comprehen- sive but more critical nature will be of greater usefulness in this Review.
Indeed, so fertile are the fields of biochemistry that the prepara- tion of complete and comprehensive surveys of the rapidly growing literature would tax beyond measure the ingenuity and industry of the chronicler. New journals are being born over night and little if any abatement is yet evident in the flood of papers to the old. On vitamins alone no less than 1,000 papers are reported to have been published in the past year. In the present volume almost 3,000 papers in twenty-five different fields have actually received review. We are satisfied that this represents less than half of the papers of sufficient merit and weight to deserve treatment.
The selection of the papers has presented numerous difficulties to the reviewers. Many were put aside because they dealt with isolated topics which cannot yet be profitably reviewed. Others pertained to questions of major importance and interest but, because of the exi- gencies of space, were deliberately reserved for treatment in the next or a later volume. Still others may have been inadvertently over- looked.
The task of the reviewers has been somewhat lightened by the cordial co-operation of the many who have been good enough to send reprints of recent publications. These have proved of special value particularly in the case of works appearing in journals not readily accessible to the reviewer.
Others have displayed their interest by suggesting ways in which the usefulness of the Reviete might be further enhanced through changes or additions in content. The growth of a subject is charac terized by its fluidity. Activity in biochemical research shifts from field to field, and interest waxes and wanes. Such transitions in em- phasis require recognition. From time to time certain sections must be expanded and others reduced. New topics deserving of review must be included in replacement of the old. The Committee will con- tinue to welcome most warmly all suggestions bearing on these and kindred matters.
Again we wish to acknowledge gratefully the support which the Review enjoys from the Chemical Foundation. Without its endorse- ment and financial aid, inception of the enterprise would have pre- sented the most serious difficulties.
To the Stanford University Press our thanks are due for their patience and care in composition, and for the excellence of their workmanship.
It is the hope of all connected with the Review the authors, the editor, the advisory committee, and the Press-that the present vol- ume may deserve no less fully the generous support received by that of last year
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